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KMID : 1036020210100010088
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지질.동맥경화학회지
2021 Volume.10 No. 1 p.88 ~ p.98
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Hypertriglyceridemia Is an Independent Risk Factor for Cardiovascular Diseases in Korean Adults Aged 30?49 Years: a Nationwide Population-Based Study
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Koo Bo-Kyung
Park Sang-Hyun
Han Kyung-Do
Moon Min-Kyong
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Abstract
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Objective: This study was conducted to estimate the incidence of cardiovascular disease (CVD) independently from low-density lipoprotein (LDL) cholesterol according to triglyceride (TG) levels in young adults.
Methods: Subjects aged 30?49 years with data from routine health check-ups provided by the National Health Insurance Service during 2009 were selected. The primary outcome was incident CVD, defined as a composite of ischemic heart disease and ischemic stroke during the follow-up period from 2009 to 2018.
Results: The mean age of study subjects (n=1,823,537) was 40.1±5.7 years, and the median follow-up period was 8.3 years. The quartiles of serum TG levels at the baseline were calculated: Q1, <74 mg/dL; Q2, 74?108 mg/dL; Q3, 109?166 mg/dL; and Q4: >166 mg/dL. The highest quartile of TG levels (Q4) had a significantly higher risk of the primary outcome than Q1 (hazard ratio [HR], 2.40 [95% confidence interval; CI, 2.33?2.47]). Q2 and Q3 also experienced the primary outcome more frequently than Q1 (HR, 1.37 [95% CI, 1.33?1.42] and HR, 1.80 [95% CI, 1.75?1.86], respectively). Even after adjustment for age, sex, obesity, alcohol drinking amount, smoking, LDL cholesterol, diabetes mellitus, hypertension, lipid-lowering medication use, and family history of CVD, there was a significant dose-response relationship between TG quartiles and the risk of the primary outcome (HR per quartile, 1.13 [95% CI, 1.12?1.14]).
Conclusion: In conclusion, in the Korean population aged 30?49 years, high TG levels independently increased future CVD risk in both men and women.
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KEYWORD
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Cardiovascular diseases, Triglycerides, Insurance claims analysis
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